Saturday, February 9, 2013

At Free Geek, Computer Repair Paves the Path to Jobs : TreeHugger


iFixit/CC BY 3.0

"One of our jobs as human beings is to help make other people smile," Cindy says as she shows me around?Free Geek. Amidst the disarray of torn apart monitors, data-wiped hard drives, and ribbon cables, Cindy sits proudly at her workstation where she volunteers assembling computers as part of Free Geek?s?Build Program.

Located on the east side of Portland, Oregon, Free Geek is a non-profit reuse organization. Its?mission: provide access to computers, the internet, education, and job skills to the local community. Like iFixit, Free Geek maintains that?repair, refurbishment, and reuse are better than recycling. Instead of becoming scrap metal, an older computer can be updated and used again??in other words, refurbishment gives technology a second useful life.

That?s why Cindy and others volunteer at Free Geek: they want to help put technology into the hands of the people who really need it. But there?s an added perk: this nonprofit teaches their volunteers valuable technological skills for the computer age. Many come to Free Geek with little prior knowledge of computers. ?By the time they leave,? says Free Geek Reuse Program Coordinator Sean Ellefson, they are ?able to do a lot.?

HK poor in cages shows dark side of property boom

In this Jan. 25, 2013 photo, 77-year-old Yeung Ying Biu sits inside his 1.5 square meter (16 square feet) cage, which he calls home, in Hong Kong. For many of the richest people in Hong Kong, one of Asia's wealthiest cities, home is a mansion with an expansive view from the heights of Victoria Peak. For some of the poorest, home is a metal cage. Some 100,000 people in the former British colony live in what's known as inadequate housing, according to the Society for Community Organization, a social welfare group. (AP Photo/Vincent Yu)

In this Jan. 25, 2013 photo, 77-year-old Yeung Ying Biu sits inside his 1.5 square meter (16 square feet) cage, which he calls home, in Hong Kong. For many of the richest people in Hong Kong, one of Asia's wealthiest cities, home is a mansion with an expansive view from the heights of Victoria Peak. For some of the poorest, home is a metal cage. Some 100,000 people in the former British colony live in what's known as inadequate housing, according to the Society for Community Organization, a social welfare group. (AP Photo/Vincent Yu)

In this Jan. 25, 2013 photo, 62-year-old Cheng Man Wai lays in his cage, measuring 1.5 square meters (16 square feet), which he calls home, in Hong Kong. For many of the richest people in Hong Kong, one of Asia's wealthiest cities, home is a mansion with an expansive view from the heights of Victoria Peak. For some of the poorest, home is a metal cage. Some 100,000 people in the former British colony live in what's known as inadequate housing, according to the Society for Community Organization, a social welfare group. (AP Photo/Vincent Yu)

In this Jan. 25, 2013 photo, 63-year-old Lee Tat-fong, walks in a corridor while her two grandchildren Amy, 9, and Steven, 13 sit in their 50-square-foot room in Hong Kong. Lee, like many poor residents, has applied for public housing but faces years of waiting. Nearly three-quarters of 500 low-income families questioned by Oxfam Hong Kong in a recent survey had been on the list for more than 4 years without being offered a flat. (AP Photo/Vincent Yu)

A maid walks a dog outside luxury houses on Victoria Peak, Hong Kong's most exclusive neighborhood, Thursday, Feb. 7, 2013. For many of the richest people in Hong Kong, one of Asia's wealthiest cities, home is a mansion with an expansive view from the heights of Victoria Peak. For some of the poorest, home is a metal cage. Some 100,000 people in the former British colony live in what's known as inadequate housing, according to the Society for Community Organization, a social welfare group. (AP Photo/Vincent Yu)

In this Jan. 25, 2013 photo, 77-year-old Yeung Ying Biu sits partially inside the cage, measuring 1.5 square meters (16 square feet), which he calls home, in Hong Kong. For many of the richest people in Hong Kong, one of Asia's wealthiest cities, home is a mansion with an expansive view from the heights of Victoria Peak. For some of the poorest, home is a metal cage. Some 100,000 people in the former British colony live in what's known as inadequate housing, according to the Society for Community Organization, a social welfare group. (AP Photo/Vincent Yu)

(AP) ? For many of the richest people in Hong Kong, one of Asia's wealthiest cities, home is a mansion with an expansive view from the heights of Victoria Peak. For some of the poorest, like Leung Cho-yin, home is a metal cage.

The 67-year-old former butcher pays 1,300 Hong Kong dollars ($167) a month for one of about a dozen wire mesh cages resembling rabbit hutches crammed into a dilapidated apartment in a gritty, working-class West Kowloon neighborhood.

The cages, stacked on top of each other, measure 1.5 square meters (16 square feet). To keep bedbugs away, Leung and his roommates put thin pads, bamboo mats, even old linoleum on their cages' wooden planks instead of mattresses.

"I've been bitten so much I'm used to it," said Leung, rolling up the sleeve of his oversized blue fleece jacket to reveal a red mark on his hand. "There's nothing you can do about it. I've got to live here. I've got to survive," he said as he let out a phlegmy cough.

Some 100,000 people in the former British colony live in what's known as inadequate housing, according to the Society for Community Organization, a social welfare group. The category also includes apartments subdivided into tiny cubicles or filled with coffin-sized wood and metal sleeping compartments as well as rooftop shacks. They're a grim counterpoint to the southern Chinese city's renowned material affluence.

Forced by skyrocketing housing prices to live in cramped, dirty and unsafe conditions, their plight also highlights one of the biggest headaches facing Hong Kong's unpopular Beijing-backed leader: growing public rage over the city's housing crisis.

Leung Chun-ying took office as Hong Kong's chief executive in July pledging to provide more affordable housing in a bid to cool the anger. Home prices rose 23 percent in the first 10 months of 2012 and have doubled since bottoming out in 2008 during the global financial crisis, the International Monetary Fund said in a report last month. Rents have followed a similar trajectory.

The soaring costs are putting decent homes out of reach of a large portion of the population while stoking resentment of the government, which controls all land for development, and a coterie of wealthy property developers. Housing costs have been fuelled by easy credit thanks to ultralow interest rates that policymakers can't raise because the currency is pegged to the dollar. Money flooding in from mainland Chinese and foreign investors looking for higher returns has exacerbated the rise.

In his inaugural policy speech in January, the chief executive said the inability of the middle class to buy homes posed a threat to social stability and promised to make it a priority to tackle the housing shortage.

"Many families have to move into smaller or older flats, or even factory buildings," he said. "Cramped living space in cage homes, cubicle apartments and sub-divided flats has become the reluctant choice for tens of thousands of Hong Kong people," he said, as he unveiled plans to boost supply of public housing in the medium term from its current level of 15,000 apartments a year.

His comments mark a distinct shift from predecessor Donald Tsang, who ignored the problem. Legislators and activists, however, slammed Leung for a lack of measures to boost the supply in the short term. Some 210,000 people are on the waiting list for public housing, about double from 2006. About a third of Hong Kong's 7.1 million population lives in public rental flats. When apartments bought with government subsidies are included, the figure rises to nearly half.

Anger over housing prices is a common theme in increasingly frequent anti-government protests. Legislator Frederick Fung warns there will be more if the problem can't be solved. He compared the effect on the poor to a lab experiment.

"When we were in secondary school, we had some sort of experiment where we put many rats in a small box. They would bite each other," said Fung. "When living spaces are so congested, they would make people feel uneasy, desperate," and angry at the government, he said.

Leung, the cage dweller, had little faith that the government could do anything to change the situation of people like him.

"It's not whether I believe him or not, but they always talk this way. What hope is there?" said Leung, who has been living in cage homes since he stopped working at a market stall after losing part of a finger 20 years ago. With just a Grade 7 education, he was only able to find intermittent casual work. He hasn't applied for public housing because he doesn't want to leave his roommates to live alone and expects to spend the rest of his life living in a cage.

His only income is HK$4,000 ($515) in government assistance each month. After paying his rent, he's left with $2,700 ($350), or about HK$90 ($11.60) a day.

"It's impossible for me to save," said Leung, who never married and has no children to lean on for support.

Leung and his roommates, all of them single, elderly men, wash their clothes in a bucket. The bathroom facilities consist of two toilet stalls, one of them adjoining a squat toilet that doubles as a shower stall. There is no kitchen, just a small room with a sink. The hallway walls have turned brown with dirt accumulated over the years.

While cage homes, which sprang up in the 1950s to cater mostly to single men coming in from mainland China, are becoming rarer, other types of substandard housing such as cubicle apartments are growing as more families are pushed into poverty. Nearly 1.19 million people were living in poverty in the first half of last year, up from 1.15 million in 2011, according to the Hong Kong Council Of Social Services. There's no official poverty line but it's generally defined as half of the city's median income of HK$12,000 ($1,550) a month.

Many poor residents have applied for public housing but face years of waiting. Nearly three-quarters of 500 low-income families questioned by Oxfam Hong Kong in a recent survey had been on the list for more than 4 years without being offered a flat.

Lee Tat-fong, is one of those waiting. The 63-year-old is hoping she and her two grandchildren can get out of the cubicle apartment they share in their Wan Chai neighborhood, but she has no idea how long it will take.

Lee, who suffers from diabetes and back problems, takes care of Amy, 9, and Steven, 13, because their father has disappeared and their mother ? her daughter ? can't get a permit to come to Hong Kong from mainland China. An uncle occasionally lends a hand.

The three live in a 50-square-foot room, one of seven created by subdividing an existing apartment. A bunk bed takes up half the space, a cabinet most of the rest, leaving barely enough room to stand up in. The room is jammed with their possessions: plastic bags filled with clothes, an electric fan, Amy's stuffed animals, cooking utensils.

"There's too little space here. We can barely breathe," said Lee, who shares the bottom bunk with her grandson.

They share the communal kitchen and two toilets with the other residents. Welfare pays their HK$3,500 monthly rent and the three get another HK$6,000 for living expenses but the money is never enough, especially with two growing children to feed. Lee said the two often wanted to have McDonalds because they were still hungry after dinner, which on a recent night was meager portions of rice, vegetables and meat.

The struggle to raise her two grandkids in such conditions was wearing her out.

"It's exhausting," she said. "Sometimes I get so pent up with anger, and I cry but no one sees because I hide away."

___

Follow Kelvin Chan at twitter.com/chanman

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2013-02-07-Hong%20Kong-The%20Rich%20And%20The%20Caged/id-5e61237db1a1413fa3d8e99394cb7e51

devils dodgers rachel maddow gia la riots new jersey devils torn acl

Friday, February 8, 2013

Investment Analyst | Aarknet Jobs

Job posted on 2013-Feb-07
Jobs in your Facebook Feed Never miss another job opportunity.
Get Jobs in your Facebook Feed!

Go back to the Job List

?

This leading Abu Dhabi based fund is currently looking to hire an experienced Investment Analyst to work within their Investments team. The core responsibility of this role is to propose the appointment and / or termination of mandates to the CIO. The successful candidate will also monitor the equities and fixed income managers performance.

Other key responsibilities will include:

  • Identify, research and recommend potential fund managers to the business whose values and investment approach align with those of the business.
  • Perform performance analysis both internally and externally and communicate results and recommendations to senior management.
  • Suggest ways of improving or changing the fund?s investment thesis.
  • Sector and fund analysis.
  • Ad hoc project based work as it comes through.

In terms of experience, you will have:

  • A minimum of five years experience working within an Investment Management / Analysis position.
  • Previous experience making recommendations on Fund Managers in the market.
  • Involvement in designing and implementing investment guidelines for specific accounts.
  • A strong mathematical background.
  • Strong presentation and communication ideas.

Apply here:

http://jobs.efinancialcareers-gulf.com/job-4000000001149747.htm?utm_campaign=JS_ME_ALLJOBS&ut m_source=EMEA_ME_ENG&utm_medium=AG_GULFJOBSITES


Source: http://www.aarknet.org/job/investment-analyst/7757

chase Adam Lanza Facebook the hobbit mick jagger Newton Shooting Newtown Shooting Gangnam Style

Wednesday, February 6, 2013

Kidnapped Boy Held In Alabama Bunker, Happy To Be Home With ...

MIDLAND CITY, Ala. ? The man who held a 5-year-old boy captive for nearly a week engaged in a firefight with SWAT agents storming his underground bunker before he was killed during the rescue operation, the FBI said Tuesday night. Also, bomb technicians scouring the property found two explosive devices, one in the bunker, the other in a plastic pipe negotiators used to communicate with the man.

Officers killed 65-year-old Jimmy Lee Dykes Monday, said a law enforcement official in Midland City, speaking on condition of anonymity. The bunker raid came six days after Dykes boarded a school bus, fatally shot the driver and abducted the boy, who by all accounts was unharmed.

Dykes "reinforced the bunker against any attempted entry by law enforcement," FBI Special Agent Jason Pack said in an email. The devices found were "disrupted," Pack said, though he did not say whether that meant they were detonated or disarmed. Officers will continue into Wednesday to sweep the 100-acre property and when they finish, investigators can more thoroughly investigate, Pack said.

For days, officers passed food, medicine, toys and other items into the bunker, which was similar to a tornado shelter and apparently had running water, heat and cable television.

On Monday, authorities said Dykes had a gun and appeared increasingly agitated, though it's unclear exactly how his behavior changed. Negotiations ? the details of which have not been made public ? were deteriorating. Agents stormed the bunker, whisking the boy to safety and leaving Dykes dead. The official who confirmed that officers killed Dykes requested anonymity because the person was not authorized to speak publicly about the investigation.

Neighbors said they heard what sounded like explosions and gunshots, though the FBI and local authorities would not confirm if shots were fired or explosives detonated.

By all accounts, despite his ordeal, the 5-year-old appeared to be acting like a normal kid, people around him say. He was running around, playing with a toy dinosaur and other action figures, eating a turkey sandwich and watching "SpongeBob SquarePants," relatives and Dale County Sheriff Wally Olson said.

"We know he's OK physically, but we don't know how he is mentally," Betty Jean Ransbottom, the boy's grandmother, told The Associated Press on Tuesday. She added that she feared the ordeal would stay with the child, who turns 6 on Wednesday, the rest of his life.

An FBI agent had been staying with the family, and relatives learned of the child's rescue after another agent at the scene called the person who was with them.

The family was relieved and grateful for all the support in a community where ribbons, fliers and vigils all symbolized the prayers for the safe return of the boy, whom law enforcement officials have identified by his first name, Ethan.

The boy's mother, in a statement released by the FBI, expressed her thanks for all the hard work of so many officers to bring her son home. The woman declined to be identified, the statement said.

"For the first time in almost a week, I woke up this morning to the most beautiful sight ... my sweet boy," she said. "I can't describe how incredible it is to hold him again."

Dale County Coroner Woodrow Hilboldt said Tuesday that he had not been able to confirm exactly how Dykes died because the man's body remained in the bunker. An autopsy was to be conducted in Montgomery once the body is taken away.

It also wasn't clear how authorities knew Dykes was armed, or what kind of surveillance they used to track his behavior and movement. Pack did not address the questions in Tuesday's email.

At the request of law enforcement authorities, Secretary of Defense Leon Panetta had approved the provision of certain equipment that could be employed to assist in the hostage situation, according to a U.S. official who requested anonymity to discuss a pending law enforcement matter. It is not clear whether the equipment was actually used.

In Midland City, a town of about 2,400 nestled among peanut and cotton fields, residents were relieved that the boy was safely rescued from Dykes, a man neighbors described as an unstable menace who beat a dog to death and threatened to shoot trespassers.

Children and teachers were trying to get back to normal, though some children who were on the bus where Dykes killed the driver have not yet returned to school, said Donny Bynum, superintendent of Midland City schools. Counselors and clergy are at the school to help any distraught students.

Officials hope to eventually throw a party to celebrate the boy's sixth birthday and to honor the memory of Charles Albert Poland Jr., the slain bus driver. No date has been set, Bynum said.

Midland City Elementary School principal Phillip Parker said he stands at the entrance to the school every day as the children arrive. The boy is a friendly, energetic child who comes up, shakes his hand and then continues on into the school as if he's in a hurry, Parker said.

The boy gave his mother a big hug at the hospital, where officers gave him a teddy bear, Olson said.

"He's just a bundle of joy," Olson said.

For now, the boy's family just wants things to go back to normal ? for all the reporters to go home, for him to be like any other kid.

"He has gone through a terrible ordeal, and I don't know if he will ever get over it," said Debra Cook, the boy's great aunt. "I just want him to be all right."

___

Associated Press writer Phillip Rawls in Montgomery, Ala., and Lolita Baldor in Washington contributed to this report.

Also on HuffPost:

"; var coords = [-5, -72]; // display fb-bubble FloatingPrompt.embed(this, html, undefined, 'top', {fp_intersects:1, timeout_remove:2000,ignore_arrow: true, width:236, add_xy:coords, class_name: 'clear-overlay'}); });

Source: http://www.huffingtonpost.com/2013/02/05/ethan-kidnapped-boy-alabama-bunker-happy_n_2621451.html

lionel richie kenny rogers avatar the last airbender david wright cory booker cubs cj wilson

Study to test whether hearing aids can help prevent falls

Study to test whether hearing aids can help prevent falls [ Back to EurekAlert! ] Public release date: 6-Feb-2013
[ | E-mail | Share Share ]

Contact: Emily Martinez
emily.martinez@utdallas.edu
214-905-3049
University of Texas at Dallas

UT Dallas research to focus on how hearing impairments affect sense of balance

UT Dallas researchers are recruiting patients for a new study aimed at determining a connection between hearing deficits and the likelihood of falls.

The research project, a collaboration between The University of Texas at Dallas and UNT Health Science Center in Fort Worth, is evaluating how much hearing aids and other technologies might improve balance and prevent falls for people with auditory problems.

One-third of older adults fall each year, according to recent national studies. The resulting injuries can be life-threatening.

A person's sense of balance relies heavily on the vestibular system of the inner ear, as well as on information gained from the senses of sight, touch and hearing. Previous research on falls has focused on the roles played by visual, cognitive or motor impairments. But recent studies suggest that people with hearing loss also may be at greater risk of falling.

More than half of adults over the age of 65 experience hearing loss. About 65 percent of them seek no treatment.

The study will help identify people at risk of falling and evaluate the effects of different types of hearing aid technologies on balance and gait. Subjects with and without hearing loss, while wearing or not wearing the hearing aids, will be monitored as they stand, walk and perform routine daily tasks while repeating words or sentences that are played in the surrounding environment.

Participants will stand or walk on a treadmill through different virtual environments, such as a walk in the forest. The researchers want to evaluate the participants in "normal" daily environments. Previous studies of hearing and balance rarely replicated real-life situations, so results were questionable, said Dr. Linda Thibodeau, a professor in UT Dallas' School of Behavioral and Brain Sciences and the chief investigator for the UT Dallas team.

The study also will provide volunteer subjects with overall assessments of their hearing and balance systems. The auditory and vestibular testing and hearing aid fitting will take place at the UT Dallas Callier Center for Communication Disorders. If a hearing loss is confirmed, the audiologist will perform a hearing aid evaluation and selection.

People with hearing loss will be equipped with bilateral hearing aids and FM systems for a six-week period. The study requires four to five visits, taking a total of 10 to 12 hours, scheduled over a period of six to eight weeks.

The second phase of the study, looking at balance and mobility, will take place at the UNT center in Fort Worth. Dr. Nicoleta Bugnariu, associate professor at UNT, is lead investigator for the project.

Reflective sensors will be placed on the arms, legs and the body to measure patients' various aspects of gait and balance. A harness is provided for patient safety during the testing.

Researchers will compare the base-line test results gathered before amplification with the results noted after six weeks of amplification to determine whether balance improves when the participant is able to hear better in the noisy environment.

The investigators are seeking 10 adults, ages 50 to 80 years, who have normal hearing and another 10 who have hearing loss but have never worn a hearing aid.

"We anticipate that there will be increased cognitive resources available to devote to balance and gait when the hearing aids or assistive devices are worn," Thibodeau said. "But until we observe these individuals in situations that are created to simulate normal day-to-day environments, we can't be certain of the effects. This study could go a long way toward helping us understand the importance of hearing and how it affects many other aspects of a person's well-being."

###

The study is funded by a $100,000 grant from the Texas Medical Research Collaborative to UT Dallas and UNT Health Science Center. Other UT Dallas researchers and students are involved in the project, including Dr. Ross Roeser, Lois & Howard Wolf Professor in Pediatric Hearing, and Dr. Phillip Wilson, clinical associate professor.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Study to test whether hearing aids can help prevent falls [ Back to EurekAlert! ] Public release date: 6-Feb-2013
[ | E-mail | Share Share ]

Contact: Emily Martinez
emily.martinez@utdallas.edu
214-905-3049
University of Texas at Dallas

UT Dallas research to focus on how hearing impairments affect sense of balance

UT Dallas researchers are recruiting patients for a new study aimed at determining a connection between hearing deficits and the likelihood of falls.

The research project, a collaboration between The University of Texas at Dallas and UNT Health Science Center in Fort Worth, is evaluating how much hearing aids and other technologies might improve balance and prevent falls for people with auditory problems.

One-third of older adults fall each year, according to recent national studies. The resulting injuries can be life-threatening.

A person's sense of balance relies heavily on the vestibular system of the inner ear, as well as on information gained from the senses of sight, touch and hearing. Previous research on falls has focused on the roles played by visual, cognitive or motor impairments. But recent studies suggest that people with hearing loss also may be at greater risk of falling.

More than half of adults over the age of 65 experience hearing loss. About 65 percent of them seek no treatment.

The study will help identify people at risk of falling and evaluate the effects of different types of hearing aid technologies on balance and gait. Subjects with and without hearing loss, while wearing or not wearing the hearing aids, will be monitored as they stand, walk and perform routine daily tasks while repeating words or sentences that are played in the surrounding environment.

Participants will stand or walk on a treadmill through different virtual environments, such as a walk in the forest. The researchers want to evaluate the participants in "normal" daily environments. Previous studies of hearing and balance rarely replicated real-life situations, so results were questionable, said Dr. Linda Thibodeau, a professor in UT Dallas' School of Behavioral and Brain Sciences and the chief investigator for the UT Dallas team.

The study also will provide volunteer subjects with overall assessments of their hearing and balance systems. The auditory and vestibular testing and hearing aid fitting will take place at the UT Dallas Callier Center for Communication Disorders. If a hearing loss is confirmed, the audiologist will perform a hearing aid evaluation and selection.

People with hearing loss will be equipped with bilateral hearing aids and FM systems for a six-week period. The study requires four to five visits, taking a total of 10 to 12 hours, scheduled over a period of six to eight weeks.

The second phase of the study, looking at balance and mobility, will take place at the UNT center in Fort Worth. Dr. Nicoleta Bugnariu, associate professor at UNT, is lead investigator for the project.

Reflective sensors will be placed on the arms, legs and the body to measure patients' various aspects of gait and balance. A harness is provided for patient safety during the testing.

Researchers will compare the base-line test results gathered before amplification with the results noted after six weeks of amplification to determine whether balance improves when the participant is able to hear better in the noisy environment.

The investigators are seeking 10 adults, ages 50 to 80 years, who have normal hearing and another 10 who have hearing loss but have never worn a hearing aid.

"We anticipate that there will be increased cognitive resources available to devote to balance and gait when the hearing aids or assistive devices are worn," Thibodeau said. "But until we observe these individuals in situations that are created to simulate normal day-to-day environments, we can't be certain of the effects. This study could go a long way toward helping us understand the importance of hearing and how it affects many other aspects of a person's well-being."

###

The study is funded by a $100,000 grant from the Texas Medical Research Collaborative to UT Dallas and UNT Health Science Center. Other UT Dallas researchers and students are involved in the project, including Dr. Ross Roeser, Lois & Howard Wolf Professor in Pediatric Hearing, and Dr. Phillip Wilson, clinical associate professor.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-02/uota-stt020613.php

breaking bad food network star British Open 2012 bane Aurora Colorado Rajesh Khanna friday the 13th

Injection-free vaccination technique could address global vaccine challenge for HIV, malaria

Injection-free vaccination technique could address global vaccine challenge for HIV, malaria

Tuesday, February 5, 2013

Scientists at King's College London have demonstrated the ability to deliver a dried live vaccine to the skin without a traditional needle, and shown for the first time that this technique is powerful enough to enable specialised immune cells in the skin to kick-start the immunising properties of the vaccine.

Funded by the Bill & Melinda Gates Foundation and published today in Proceedings of the National Academy of Sciences, researchers say although it is an early study this important technical advance offers a potential solution to the challenges of delivering live vaccines in resource-limited countries globally, without the need for refrigeration. A cheaper alternative to hypodermic needles, it would also remove safety risks from needle contamination and the pain-free administration could lead to more people taking up a vaccination. The researchers add that it could have an impact beyond infectious disease vaccination programmes, for example managing autoimmune and inflammatory conditions such as diabetes.

HIV, malaria and TB represent major global health challenges. Although promising research is underway to develop vaccines for these diseases, considerable stumbling blocks remain for countries where transporting and storing live vaccines in a continuously cold environment (around 2?C to 8?C or below) would not be possible. If a cold chain cannot be maintained for a live vaccine there is a high risk it could become unsafe and lose effectiveness.

The team at King's used a silicone mould developed by US company TheraJect to create a microneedle array ? a tiny disc with several micro-needles made of sugar which dissolve when inserted into the skin. The team formulated a dried version of a live modified adenovirus-based candidate HIV vaccine in sugar (sucrose) and used the mould to create the microneedle array. They found that the dried live vaccine remained stable and effective at room temperature.

To test the effectiveness of the microneedle array, they applied it to mice. Using imaging (in collaboration with Professor Frederic Geissmann, King's College London) they observed how the vaccine dissolved in the skin and were able to identify for the first time exactly which specialised immune cells in the skin 'pick up' this type of vaccine and activate the immune system. The researchers found the first evidence that a sub-set of specialised dendritic cells in the skin were responsible for triggering this immune response.

When compared with a traditional needle vaccine method, the immune response generated by the dried microneedle vaccine (kept at room temperature) was equivalent to that induced by the same dose of injected liquid vaccine that had been preserved at -80?C.

Dr Linda Klavinskis from the Peter Gorer Department of Immunobiology at King's College London, said: 'We have shown that it is possible to maintain the effectiveness of a live vaccine by drying it in sugar and applying it to the skin using microneedles ? a potentially painless alternative to hypodermic needles. We have also uncovered the role of specific cells in the skin which act as a surveillance system, picking up the vaccine by this delivery system and kick-starting the body's immune processes.

'This work opens up the exciting possibility of being able to deliver live vaccines in a global context, without the need for refrigeration. It could potentially reduce the cost of manufacturing and transportation, improve safety (as there would be no loss in potency), and avoids the need of hypodermic needle injection, reducing the risk of transmitting blood-borne disease from contaminated needles and syringes.

'This new technique represents a huge leap forward in overcoming the challenges of delivering a vaccination programme for diseases such as HIV and malaria. But these findings may also have wider implications for other infectious disease vaccination programmes, for example infant vaccinations, or even other inflammatory and autoimmune conditions such as diabetes.'

###

King's College London: http://www.kcl.ac.uk

Thanks to King's College London for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 48 time(s).

Source: http://www.labspaces.net/126627/Injection_free_vaccination_technique_could_address_global_vaccine_challenge_for_HIV__malaria

how to cook a turkey emma stone Frys tryptophan BestBuy.com Kohls Black Friday www.walmart.com

Constitution Check: Is the War Powers Clause a dead letter in the Cyberspace Age?

computer serversDoes the Constitution give the president the power to conduct cyber-warfare? Lyle Denniston looks a new issue involving the War Powers Clause.

The statement at issue:

?A secret legal review of the use of America?s growing arsenal of cyber-weapons has concluded that President Obama has the broad power to order a pre-emptive strike if the United States detects credible evidence of a major digital attack looming from abroad?New policies will govern how the intelligence agencies can carry out searches of faraway computer networks for signs of potential attacks on the United States and, if the president approves, attack adversaries by injecting them with destructive code ? even if there is no declared war.?

?? Lead story in The New York Times, February 4, under the headline ?Broad Powers Seen for Obama in Cyberstrikes,? by reporters David E. Sanger and Thom Shanker.

We checked the Constitution, and?

checkThose who wrote the Constitution didn?t want the president to be able to take the nation to war without the consent of Congress. They were willing to allow the president to act on the basis of presidential authority alone to repel sudden attacks, but that was understood to be a grant of authority for the short term only. Since then, of course, America has gone to war over and over again, and yet Congress has formally declared such a conflict only five times; the most recent was World War II.

The debate among the Founders over the difference between ?making war? and ?declaring war? has actually never ended, and government officials, lawmakers, and scholars to this day regularly engage each other in sometimes heated exchanges over who can commit U.S. military forces to actual hostilities that, for all that appears, are wars even if not given that name by Congress.

In the George W. Bush administration, government lawyers advised the White House in the wake of the 9/11 terrorist attacks that the president could act alone?as commander in chief?to send U.S. military forces overseas to engage in war-like operations, ?especially in response to grave national emergencies created by sudden, unforeseen attacks on the people and territory of the United States,? as the main legal memo put it.

The Obama administration embraces that view, just as fully, and perhaps even more so. In fact, internal but still-secret legal memos apparently exist in support of presidential authority to go beyond the counter-insurgency operations of the Iraq and Afghanistan ?wars,? to engage in entirely new forms of military action.

News organizations have turned up evidence that there is at least one internal document that provides a legal defense for President Obama?s policy of using unmanned but precision-guided aerial drones explicitly to attack and kill leaders of terrorist networks, such as Al Qaeda. There have been two attempts to challenge that legal conclusion in federal court lawsuits, but both have come to nothing; the courts have been unwilling to second-guess that policy on any legal grounds.

About Constitution Check

  • In a continuing series of posts, Lyle Denniston provides responses based on the Constitution and its history to public statements about its meaning and what duties it imposes or rights it protects.

Now, it appears from an account in The New York Times and recent stories in other major media that the Obama administration is developing a broad new policy?with the support of secret legal memos?to engage in ?cyber-warfare.? Only very digitally savvy experts can know, or guess, how such attacks will be carried out, but they apparently have the capacity to completely demobilize an entire nation?s electronic communications network, or at least to disable a specific target for an assault with a destructive computer code.

Once more, though, the legal justification for this sweeping war-making power does not exist in public, and therefore its basis in the Constitution?or lack of any such basis?cannot be analyzed and debated. There is no such thing, in short, as transparency in the arguments that the president alone can take the nation into digital warfare.

It is possible, and probably even likely, that there are committees of Congress who are let in on the secret of cyber war-making and its legal rationale. But that, too, is not open for public examination.

If one were to return to the Constitution and its War Powers Clause, one might ask what value was there in requiring that Congress ?declare? war before the government could ?wage? war? Probably the main value was the promotion of political accountability: if one is prepared to authorize war, one must be prepared to defend that choice to the voters and to the community at large.

A secondary virtue, perhaps, was the understanding that waging war required more than military effort, and might even require the full mobilization of society?s resources in order to perform that task successfully. It would be important, therefore, to have the American public on board before such a task was undertaken.

When sketchy news accounts, based on unidentified sources, are the only evidence to suggest that the government is about to enter a new form of war-making, that does not have and cannot have the same effect as a transparent act of government. To know, but only from news sources, that the government is going to begin, or continue, new acts of belligerency is not to give society?s political consent through a representative body of the government.

Such novel forms of war-making no doubt have to be surrounded in secrecy, by their very nature. But to have public discourse on whether the Constitution allows such wars, and by whose authority, does not need to get into what is secret: such a debate would be a legal argument, using public sources and precedents, and it might even be measured and reasoned. If it could happen, it could show that there is something very meaningful about the word ?declare? when used to start a war.

On Monday night, NBC News published an Obama administration ?white paper? that discusses the legal reasons for the drone policy. The network said the paper, which was not dated, is not the legal memo that has been discussed, but does attempt to provide some of the justification.? It can be read here.

Lyle Denniston is the National Constitution Center?s Adviser on Constitutional Literacy. He has reported on the Supreme Court for 54 years, currently covering it for SCOTUSblog, an online clearinghouse of information about the Supreme Court?s work.

Recent Constitution Daily Stories
Former First Dog Barney was an early web video icon
Yes, it was 100 years ago that we wound up with a national income tax
Background checks could be gun control deal breaker
10 interesting facts about young Franklin D. Roosevelt

Also Read

Source: http://news.yahoo.com/constitution-check-war-powers-clause-dead-letter-cyberspace-113217808.html

al sharpton actuary elon musk fox mole manson bubba watson recent earthquakes