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Friday, March 8, 2013
WTF-Mini Titanium Keychain ? You wont need to curse to tighten that nut
Ever need a wrench in a pinch, but just don’t have one handy? The WTF-Mini Titanium Keychain (WTF stands for Wrench That Fits) can solve that problem. Although this ?Kickstarter project?is listed as a Titanium keychain, it will also be available in aluminum. The WTF measures 2.85 inches long and 0.83 inches wide; it weighs [...]
Thursday, March 7, 2013
Disney working on standalone Star Wars movies
PHOENIX (AP) ? Star Wars fans have more than just Episodes 7, 8 and 9 to look forward to.
Disney CEO Bob Iger said at the annual shareholders meeting in Phoenix on Wednesday that the company is developing "some standalone movies" featuring Star Wars characters.
The news is likely to set off a new round of speculation about what's in store for the Lucasfilm franchise. The buzz has been at fever pitch levels since The Walt Disney Co. said in October it was acquiring the studio for $4 billion.
Iger didn't say which characters might be featured in the standalone films. Some Star Wars characters such as bounty hunter Boba Fett have been given bigger treatments in comic books.
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Bob Hope's iconic estate listed for $50 million
Palm Springs, Calif.
For sale: $50 million
Actor Bob Hope owned a collection of homes in Palm Springs and the L.A. area, and two have hit the market ? both snagging buyers within a month of listing. But the real prize of Hope's homes is the John Lautner-designed property, an architectural treasure that hit the market in late February for $50 million.
Architect John Lautner was well-known for his dramatic designs, and his biggest piece was a custom home for Bob and Dolores Hope. Perched in the private neighborhood of Southridge, the estate dominates a corner lot with sweeping views of the Coachella Valley.
Hope's 23,366-square-foot home was designed in 1973 by Lautner to resemble a volcano. The modernist structure is built of concrete and glass, with an undulating copper roof that rises to an open semi-circle at its center.
The home was used primarily as a second residence for the Hope family and was where they entertained most often, inviting friends such as crooner Tony Bennett and country music singer Glen Campbell to enjoy the views from the house.
Listed by Ann Eysenring of Partners Trust in Beverly Hills along with Patrick Jordan and Stewart Smith of Windermere Real Estate in Palm Springs, the home has six bedrooms and 12 baths. Outdoor spaces include a pool, pond, tennis court and outdoor fireplace.
The Lautner home is just the latest of the Hope estates to be listed; the final property, a custom home in Toluca Lake, Los Angeles used by the Hopes as their primary residence, has yet to be listed.
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Source: http://www.nbcnews.com/business/bob-hopes-iconic-estate-listed-50-million-1C8620900
15 Fitness Gadgets vs. One Personal Trainer
As yet, there is still no technological substitute for human willpower. But in the quest to get in shape, we flabby citizens have a long history of leaning on gadgets to get us up and active. The first pedometer design is attributed to Leo?nardo da Vinci, while Thomas Jefferson built his own such device to measure his walks. Since then vibrating belts, electric shocks, and sweaty sauna suits have been touted as high-tech routes to fitness. And in the 1980s, a former Viet Cong sympathizer leveraged the popularity of the VHS to turn herself into a domestic exercise icon with a series of workout tapes.
Believe it or not, Jane Fonda is still at it, finally upgrading to the DVD format in 2010. But her discs are lost in a sea of video games with motion-capture avatars that track your body movements and encourage/hector you in real time. And those games are just the tip of the high-tech-fitness iceberg, with a wide variety of gadgets that promise to inspire you to become a leaner, stronger, healthier you.
The gold standard for fitness coaching is the personal trainer?a real person certified as a professional exercise instructor. But hiring one can be extremely expensive?upwards of $60 per session, which could cause many clients to go broke before they get fit.
Can a bunch of high-tech doodads provide instruction and inspiration comparable to what you'd get from a trained professional? I donned my tracksuit and covered myself in sensors to find out.
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Monday, March 4, 2013
Misplaced molecules: New insights into the causes of dementia
Monday, March 4, 2013
A shortage of a protein called TDP-43 caused muscle wasting and stunted nerve cells. This finding supports the idea that malfunction of this protein plays a decisive role in ALS and FTD. The study is published in the "Proceedings of the National Academy of Sciences of the USA" (PNAS).
ALS is an incurable neurological disease which manifests as rapidly progressing muscle wasting. Both limbs and respiratory muscles are affected. This leads to impaired mobility and breathing problems. Patients commonly die within a few years after the symptoms emerged. In rare cases, of which the British physicist Stephen Hawking is the most notable, patients can live with the disease for a long time. In Germany estimates show over 150,000 patients suffering from ALS ? an average of 1 in 500 people.
Proteins gone astray
Over the last few years, there has been increasing evidence that ALS and FTD ? a form of dementia associated with changes in personality and social behaviour ? may have similar or even the same origins. The symptoms overlap and common factors have also been found at the microscopic level. In many cases, particles accumulate and form clumps in the patient's nerve cells: this applies particularly to the TDP-43 protein.
"Normally, this protein is located in the cell nucleus and is involved in processing genetic information," explains molecular biologist Dr. Bettina Schmid, who works at the DZNE Munich site and at LMU. "However, in cases of disease, TDP-43 accumulates outside the nucleus forming aggregates." Schmid explains that it is not yet clear whether these clumps are harmful. "However, the protein's normal function is clearly disrupted. It no longer reaches the nucleus to perform its actual task. There seems to be a relationship between this malfunction and the disease."
Studies on zebrafish
However, until now little was known about the function of TDP-43. What are the consequences when this protein becomes non-functional? In order to answer this question, the team led by Bettina Schmid cooperated with the research group of Prof. Christian Haass to investigate the larvae of specially bred zebrafish. Their genetic code had been modified in such a way that no TDP-43 was produced in the organism of the fish. The result: the young fish showed massive muscle wasting and died a few days after hatching. Moreover, the extensions of the nerve cells which control the muscles were abnormal.
"To some extent, these are symptoms typical of ALS and FTD. Therefore, a loss of function of TDP-43 does seem to play a critical role in the disease," says Haass, Site Speaker of the DZNE Munich Site and chair of Metabolic Biochemistry at LMU.
The study revealed one more finding which surprised the researchers: the blood flow of the fish was massively disturbed. "It is well known that circulatory disorders play a part in other forms of dementia, notably in the case of Alzheimer's," says Haass. "We now want to investigate whether such problems with blood flow may be a general problem of neurodegenerative diseases and whether such problems occur particularly in patients with ALS and FTD."
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Helmholtz Association of German Research Centres: http://www.helmholtz.de/en/index.html
Thanks to Helmholtz Association of German Research Centres for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Source: http://www.labspaces.net/127105/Misplaced_molecules__New_insights_into_the_causes_of_dementia
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